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About us

 

Proteomics: that's what it is all about ...

 

With the deciphering of the human genome and that of many other species, a dream of modern medical and life science has come true. However, the protein complement ('proteome') generated from a given genome is much more complex than the corresponding genome itself. In humans, for example, about half a million proteins can be generated from some 20.000 genes. Many proteins are modified after their synthesis, and their expression levels are differentially regulated in space and time or in healthy and diseased states. Thus, the proteome is a highly complex and dynamic protein network generated from an essentially static genomic blueprint. To characterize functional protein networks and their dynamic alteration during physiological and pathological processes, proteins have to be identified, quantified, and classified with respect to their function and interaction partners in a protein network. This is achieved by 'proteomics', the combination of high-resolution protein separation techniques with mass spectrometry and modern sequence database mining tools

 

 

Who we are ...

 

The Proteomics Group is a joint research unit of the Max-Planck-Institute of Experimental Medicine and the Cluster of Excellence/DFG Research Center "Nanoscale Microscopy and Molecular Physiology of the Brain" (CNMPB). Established in 2003, the group works on the development and application of gel electrophoretic, chromatographic, and mass spectrometric methods for the systematic analysis of proteins from cells, tissue or body fluids. The core technology of the laboratory comprises fully automated solutions for sample preparation to improve throughput and reproducibility of protein identification and quantification. Another focus is the design and synthesis of functionalized peptides for the characterization of biomolecular interactions (see Research for further details). Our group is a founding member of the Göttingen Proteomics Forum (GPF), a local network of proteomics scientists which recently has been integrated into the Göttingen Campus.

 

 

What we can do for you ...

 

With our neuroscientific focus, we are mainly involved in numerous in-house projects, but are also active in local CNMPB and selected external collaborations. If capacities allow, we are open to support other research groups of the Göttingen Campus with proteomics and peptide synthesis technology in line with the mission of the Göttingen Proteomics Forum. For example, we maintain a protein identification service for gel-separated protein samples on a collaborative basis. Please refer to the sections Protocols and User Registration for detailed information on how to prepare and how to submit samples for protein identification, and contact us well in advance - best already during the planning phase of your experiments. Contact information is provided in the Team Information section.



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June 05, 2019

 

Cells Special Issue "25 Years of Proteomics in Cell Biology".




 

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October 30, 2018

 

Proteomic phenotyping platform contributes to the identification of a signalling pathway regulating neuron polarity.




 

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April 16, 2018

 

SUMO and aging.




 

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