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In this section you will find selected publications of the Proteomics Group.


For complete publication records of the scientific staff, please refer to Team Information.


For further publications on myelin proteome analysis, please refer to our web resource.


For further joint publications with external partners, please refer to Collaborations.


Szego, É.M.; Dominguez-Meijide, A.; Gerhardt, E.; König, A.; Koss, D.J.; Li, W; Pinho, R.; Fahlbusch, C.; Johnson, M.; Santos, P.; Villar-Piqué, A.; Thom, T.; Rizzoli, S.; Schmitz, M.; Li, J.; Zerr, I.; Attems, J.; Jahn, O.; Outeiro, T.F. Cytosolic trapping of a mitochondrial heat shock protein is an early pathological event in synucleinopathies. Cell Reports 2019; 28:65-77.


Joseph, S.; Vingill, S.; Jahn, O.; Fledrich, R.; Werner, H.B.; Katona, I.; Möbius, W.; Mitkovski, M.; Huang, Y.; Weis, J.; Sereda, M.W.; Schulz, J.B.; Nave, K.-A.; Stegmüller, J. Myelinating glia-specific deletion of Fbxo7 in mice triggers axonal degeneration in the central nervous system together with peripheral neuropathy. Journal of Neuroscience 2019; 39:5606-5626.


López-Murcia, F.J.; Reim, K.; Jahn, O.; Taschenberger, H.; Brose, N. Acute Complexin knockout abates spontaneous and evoked transmitter release. Cell Reports 2019; 26:2521-2530.


Erwig, M.S.; Hesse, D.; Jung, R.B.; Uecker, M.; Kusch, K.; Tenzer, S.; *Jahn, O.; Werner, H.B. Myelin: Methods for purification and proteome analysis. Methods in Molecular Biology 2019; 1936:37-63 (*co-corresponding author).


Scholz, N.; Ehmann, N.; Sachidanandan, D.; Imig, C.; Cooper, B.H.; Jahn, O.; Reim, K.; Brose, N.; Meyer, J.; Lamberty, M.; Altrichter, S.; Bormann, A.; Hallermann, S.; Pauli, M.; Heckmann, M.; Stigloher, C.; Langenhan, T.; Kittel, R.J. Complexin cooperates with Bruchpilot to tether synaptic vesicles to the active zone cytomatrix. Journal of Cell Biology 2019; 218:1011-1026.


Erwig, M.S.; Patzig, J.; Steyer, A.M.; Dibaj, P.; Heilmann, M.; Heilmann, I.; Jung, R.B.; Kusch, K.; Möbius, W.; Jahn, O.; Nave, K.-A.; Werner, H.B. Anillin facilitates septin assembly to prevent pathological outfoldings of central nervous system myelin. eLife 2019; 8:e43888.


Hornung, K.; Zampar, S.; Engel, N.; Klafki, H.; Liepold, T.; Bayer, T.A.; Wiltfang, J.; Jahn, O.; Wirths, O. N-terminal truncated Aβ4-42 is a substrate for neprilysin degradation in vitro and in vivo. Journal of Alzheimer's Disease 2019; 67:849-858.


Ambrozkiewicz, M.C.; Schwark, M.; Kishimoto-Suga, M.; Borisova, E.; Hori, K.; Salazar-Lázaro, A.; Rusanova, A.; Altas, B.; Piepkorn, L.; Bessa, P.; Schaub, T.; Zhang, X.; Rabe, T.; Ripamonti, S.; Rosário, M.; Akiyama, H.; Jahn, O.; Kobayashi, T.; Hoshino, M.; Tarabykin, V.; Kawabe, H. Polarity Acquisition in Cortical Neurons Is Driven by Synergistic Action of Sox9-Regulated Wwp1 and Wwp2 E3 Ubiquitin Ligases and Intronic miR-140. Neuron 2018; 100:1097-1115.


Sondermann, J.R.; Barry, A.M.; Jahn, O.; Michel, N.; Abdelaziz, R.; Kügler, S.; Gomez-Varela, D.; Schmidt, M. Vti1b promotes TRPV1 sensitization during inflammatory pain. Pain 2018; 160:508-527.


Stankova, T.; Piepkorn, L.; Bayer, T.A.; Jahn, O.; Tirard, M. SUMO1-conjugation is altered during normal aging but not by increased amyloid burden. Aging Cell 2018; 17:e12760.


Lipstein, N.; Göth, M.; Piotrowski, C.; Pagel, K.; Sinz, A.; Jahn, O. Presynaptic Calmodulin targets: lessons from structural proteomics. Expert Review of Proteomics 2017; 14:223-242.


Lipstein, N.; Verhoeven-Duif, N. M.; Michelassi, F. E.; Calloway, N.; van Hasselt, P. M.; Pienkowska, K.; van Haaften, G.; van Haelst, M. M.; van Empelen, R.; Cuppen, I.; van Teeseling, H. C.; Evelein, A. M.; Vorstman, J. A.; Thoms, S.; Jahn, O.; Duran, K. J.; Monroe, G. R.; Ryan, T. A.; Taschenberger, H.; Dittman, J. S.; Rhee, J.-S.; Visser, G.; Jans, J. J.; Brose, N. Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder. Journal of Clinical Investigation 2017; 127:1005-1008.


Kusch, K.; Uecker, M.; Liepold, T.; Möbius, W.; Hoffmann, C.; Neumann, H.; Werner, H. B.; Jahn, O. Partial immunoblotting of 2D-gels: A novel method to identify post-translationally modified proteins exemplified for the myelin acetylome. Proteomes 2017; 5:3.


Altas, B.; Jahn, O.; Kawabe, H. Biochemical purification of binding partners of synaptic scaffold proteins. Methods in Molecular Biology 2017; 1538:69-82.


Beyer, I.; Rezaei-Ghaleh, N.; Klafki, H.-W.; Jahn, O.; Haußmann, U.; Wiltfang, J.; Zweckstetter, M.; Knölker, H.-J. Solid-phase synthesis and characterization of N-terminally elongated Aβ−3–x-peptides. Chemistry – A European Journal 2016; 22:8685-8693.


Ott, C.; Martens, H.; Hassouna, I.; Oliveira, B.; Erck, C.; Zafeiriou, M.-P.; Peteri, U.-K.; Hesse, D.; Gerhart, S.; Altas, B.; Kolbow, T.; Stadler, H.; Kawabe, H.; Zimmermann, W.-H.; Nave, K.-A.; Schulz-Schaeffer, W.; Jahn, O.; Ehrenreich, H. Widespread expression of erythropoietin receptor in brain and its induction by injury. Molecular Medicine 2015; 21:803-815.


Kuharev, J.; Navarro, P.; Distler, U.; Jahn, O.; Tenzer, S. In-depth evaluation of software tools for data-independent acquisition-based label-free quantification. Proteomics 2015; 15:3140-3151.


Matz, A.; Lee, S.-J.; Schwedhelm-Domeyer, N.; Zanini, D.; Holubowska, A.; Kannan, M.; Farnworth, M.; Jahn, O.; Göpfert, M.C.; Stegmüller, J. Regulation of neuronal survival and morphology by the E3 ubiquitin ligase RNF157. Cell Death & Differentiation 2014; 22:626-642.


Pettelkau, J.; Ihling, CH.; Frohberg, P.; van Werven, L.; *Jahn, O.; Sinz, A. Reliable Identification of Cross-Linked Products in Protein Interaction Studies by 13C-Labeled p-Benzoylphenylalanine. Journal of the American Society for Mass Spectrometry 2014; 25:1628-1641 (*co-corresponding author).


Biesemann, C.; Grønborg, M.; Luquet, E.; Wichert, S.P.; Bernard, V.; Bungers, S.R.; Cooper, B.; Varoqueaux, F.; Li, L.; Byrne, J.A.; Urlaub, H.; Jahn, O.; Brose, N.; Herzog, E. Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting. EMBO Journal 2014; 33:157-170.


Haußmann, U.; Jahn, O.; Linning, P.; Janßen, C.; Liepold, T.; Portelius, E.; Zetterberg, H.; Bauer, C.; Schuchhardt, J.; Knölker, H.-J.; Klafki, H.; Wiltfang, J. Analysis of amino-terminal variants of amyloid-b peptides by capillary isoelectric focussing immunoassay. Analytical Chemistry 2013; 85:8142-8149.


Nawaz, S.; Schweitzer, J.; Jahn, O.; Werner, H.B. Molecular evolution of myelin basic protein, an abundant structural myelin component. Glia 2013; 61:1364-1377.


Schmidt, C.; Hesse, D.; Raabe, M.; Urlaub, H.; Jahn, O. An automated in-gel digestion / iTRAQ-labeling workflow for robust quantification of gel-separated proteins. Proteomics 2013; 13:1417-22.


Lipstein, N.; Schaks, S.; Dimova, K.; Kalkhof, S.; Ihling, C.; Kölbel, K.; Ashery, U.; Rhee, J.; Brose, N.; Sinz, A.; Jahn, O. Non-conserved Ca2+/calmodulin binding sites in Munc13s differentially control synaptic short-term plasticity. Molecular and Cellular Biology 2012; 32:4628-4641.


Patzig, J.; *Jahn, O.; Tenzer, S.; Wichert, S.P.; de Monasterio-Schrader, P.; Rosfa, S.; Kuharev, J.; Yan, K.; Bormuth, I.; Bremer, J.; Aguzzi, A.; Orfaniotou, F.; Hesse, D.; Schwab, M.H.; Möbius, W.; Nave, K.-A.; Werner, H.B. Quantitative and integrative proteome analysis of peripheral nerve myelin identifies novel myelin proteins and candidate neuropathy loci. Journal of Neuroscience 2011; 31:16369-16386 (*co-first author).


Schieb, H.; Kratzin, H.; Jahn, O.; Moebius, W.; Rabe, S.; Staufenbiel, M.; Wiltfang, J.; Klafki, H.W. b-Amyloid peptide variants in brains and cerebrospinal fluid from APP transgenic mice: Comparison with human Alzheimer's amyloid. Journal of Biological Chemistry 2011; 286:33747-33758.


Sussulini, A.; Dihazi, H.; Banzato, C.E.; Arruda, M.A.; Stühmer, W.; Ehrenreich, H.; *Jahn, O.; Kratzin, H. Apolipoprotein A-I as a candidate serum marker for the response to lithium treatment in bipolar disorder. Proteomics 2011; 11:261-269 (*co-corresponding author).


Burgalossi, A.; Jung, S.; Meyer, G.; Jockusch, W.J.; Jahn, O.; Taschenberger, H.; O'Connor, V.M.; Nishiki, T.; Takahashi, M.; Brose, N.; Rhee, J.-S. SNARE protein recycling by aSNAP and bSNAP supports synaptic vesicle priming. Neuron 2010; 68:473-487.


Kawabe, H.; Neeb, A.; Dimova, K.; Young, S.M.; Takeda, M.; Katsurabayashi, S.; Mitkovski, M.; Malakhova, O.A.; Zhang, D.-E.; Umikawa, M.; Kariya, K.; Goebbels, S.; Nave, K.-A.; Rosenmund, C.; Jahn, O.; Rhee, J.-S.; Brose, N. Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development. Neuron 2010; 65:358-372.


Rodriguez-Castaneda, F.; Maestre-Martinez, M.; Coudevylle, N.; Dimova, K.; Junge, H.; Lipstein, N.; Lee, D.; Becker, S.; Brose, N.; Jahn, O.; Carlomagno, T.; Griesinger, C. Modular architecture of Munc13/calmodulin complexes: dual regulation by Ca2+ and possible role in short-term synaptic plasticity. EMBO Journal 2010; 29:680-691.

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June 05, 2019


Cells Special Issue "25 Years of Proteomics in Cell Biology".


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October 30, 2018


Proteomic phenotyping platform contributes to the identification of a signalling pathway regulating neuron polarity.


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April 16, 2018


SUMO and aging.


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